报告人：周欣 研究员
时间：
地点：东南大学物理系田家炳楼南楼205
摘要：
A method is reported for enhancing the sensitivity of NMR of dissolved xenon by detecting the signal after extraction to the gas phase. We demonstrate hyperpolarized xenon signal amplification by gas extraction (Hyper-SAGE) in both NMR spectra and magnetic resonance images with time-of-flight information. Hyper-SAGE takes advantage of a change in physical phase to increase the density of polarized gas in the detection coil. At equilibrium, the concentration of gas-phase xenon is ≈10 times higher than that of the dissolved-phase gas. After extraction the xenon density can be further increased by several orders of magnitude by compression and/or liquefaction. Additionally, being a remote detection technique, the Hyper-SAGE effect is further enhanced in situations where the sample of interest would occupy only a small proportion of the traditional NMR receiver. Coupled with targeted xenon biosensors, Hyper-SAGE offers another path to highly sensitive molecular imaging of specific cell markers by detection of exhaled xenon gas.
简历：
周欣，男，博士，研究员。
2004年在中科院武汉物理与数学研究所获博士学位；
2005年1月至2007年9月，在美国哈佛大学(Harvard University)和Brigham妇女医院(Brigham Women’s Hospital)做博士后研究；
2007年9月至2009年10月，在美国能源部劳伦斯-伯克利国家实验室(Lawrence Berkeley National Laboratory)和加州大学伯克利分校(University of California Berkeley)化学系做研究助理；
2009年10月任中科院武汉物理与数学研究所研究员。
2009年入选中科院“百人计划”。
研究领域：
主要从事磁共振波谱(NMR)和磁共振成像(MRI)新技术和新方法研究，研制和发展超极化 (Hyperpolarized)仪器装置，以超极化媒体(129Xe， 3He， 13C等)为手段，探索超灵敏度磁共振方法和分子影像技术，用于化学、生物医学、材料和物理等方面。
Selected Publications:
1. Xin Zhou, Yanping Sun, MaryMazzanti, Nils Henninger, JoeyMansour, Marc Fisher,
Mitchell Albert: MRI of Stroke using Hyperpolarized 129Xe. NMR in Biomedicine, (In
press) (2010).
2. Xin Zhou, Dominic Graziani, Alexander Pines: Hyperpolarized Xenon NMR andMRI
Signal Ampli cation by Gas Extraction. The Proceedings of the National Academy of
Sciences, USA, Vol 106, 16903-16906 (2009).
3. Xin Zhou, Xianping Sun, Jun Luo, Mingsheng Zhan, Maili Liu: Quantitative Esti-
mation of SPINOE Enhancement in Solid State. Journal of Magnetic Resonance, Vol
196, 200-203 (2009).
4. Xin Zhou, Mary Mazzanti, Jianbing James Chen, Joey Mansour, Jessica Gereige,
Yang-Sheng Tzeng, Arvind Venkatesh, Yanping Sun, Robert Mulkern, Mitchell Albert:
Reinvestigating Hyperpolarized 129Xe Longitudinal Relaxation Time in the Rat Brain
with Noise Considerations. NMR in Biomedicine, Vol 21, 217-225 (2008)
5. Xin Zhou, Jun Luo, Xian-ping Sun, Xi-zhi Zeng, Shang-wu Ding, Mai-li Liu, Ming-
sheng Zhan: Enhancement of Solid-state Proton NMR via SPINOE with Laser-polarized
Xenon. Physical Review B, Vol.70, No.5, 052405 (2004)
6. Xin Zhou, Jun Luo, Xian-ping Sun, Xi-zhi Zeng, Ming-sheng Zhan, Mai-li Liu: Ex-
perimental and Dynamic Simulations of Radiation Damping of Laser-polarized Liquid
129Xe at Low Magnetic Field in a Flow System. Applied Magnetic Resonance, Vol.26,
No.3, 327-337 (2004)
7. Xin Zhou, Xian-ping Sun, Jun Luo, Xi-zhi Zeng, Mai-li Liu, Ming-sheng Zhan: Pro-
duction of Hyerpolarized 129Xe Gas without Nitrogen by Optical Pumping at 133Cs D2
Line in Flow System. Chinese Physics Letter Vol.21, No.8, 1501-1503 (2004)